diff --git a/mypyc/irbuild/util.py b/mypyc/irbuild/util.py
index 3028e940f7f9..c2ba8f04b808 100644
--- a/mypyc/irbuild/util.py
+++ b/mypyc/irbuild/util.py
@@ -137,6 +137,12 @@ def get_mypyc_attrs(
     lines: dict[MypycAttr, int] = {}
 
     def set_mypyc_attr(key: str, value: Any, line: int) -> None:
+        if (
+            (key == "native_class" and value is False and attrs.get("allow_interpreted_subclasses") is True)
+            or (key == "allow_interpreted_subclasses" and value is True and attrs.get("native_class") is False)
+        ):
+            errors.error("'allow_interpreted_subclasses' cannot be True if 'native_class' is False"
+
         if key in MYPYC_ATTRS:
             key = cast(MypycAttr, key)
             attrs[key] = value