diff --git a/bleedingEdge.neon b/bleedingEdge.neon
index 4690264c..9d0c6cfb 100644
--- a/bleedingEdge.neon
+++ b/bleedingEdge.neon
@@ -8,3 +8,4 @@ parameters:
 			testClassSuffixNameRule: true
 			dependencySerializationTraitPropertyRule: true
 			accessResultConditionRule: true
+			cacheableDependencyRule: true
diff --git a/extension.neon b/extension.neon
index 8cd6318a..6a2e15c4 100644
--- a/extension.neon
+++ b/extension.neon
@@ -33,6 +33,7 @@ parameters:
 			accessResultConditionRule: false
 			classExtendsInternalClassRule: true
 			pluginManagerInspectionRule: false
+			cacheableDependencyRule: false
 		entityMapping:
 			aggregator_feed:
 				class: Drupal\aggregator\Entity\Feed
@@ -267,6 +268,7 @@ parametersSchema:
 			accessResultConditionRule: boolean()
 			classExtendsInternalClassRule: boolean()
 			pluginManagerInspectionRule: boolean()
+			cacheableDependencyRule: boolean()
 		])
 		entityMapping: arrayOf(anyOf(
 			structure([
diff --git a/rules.neon b/rules.neon
index 34f4b3b6..d435567a 100644
--- a/rules.neon
+++ b/rules.neon
@@ -24,6 +24,8 @@ conditionalTags:
 		phpstan.rules.rule: %drupal.rules.classExtendsInternalClassRule%
 	mglaman\PHPStanDrupal\Rules\Classes\PluginManagerInspectionRule:
 		phpstan.rules.rule: %drupal.rules.pluginManagerInspectionRule%
+	mglaman\PHPStanDrupal\Rules\Drupal\CacheableDependencyRule:
+		phpstan.rules.rule: %drupal.rules.cacheableDependencyRule%
 
 services:
 	-
@@ -38,3 +40,5 @@ services:
 		class: mglaman\PHPStanDrupal\Rules\Classes\ClassExtendsInternalClassRule
 	-
 		class: mglaman\PHPStanDrupal\Rules\Classes\PluginManagerInspectionRule
+	-
+		class: mglaman\PHPStanDrupal\Rules\Drupal\CacheableDependencyRule
diff --git a/src/Rules/Drupal/CacheableDependencyRule.php b/src/Rules/Drupal/CacheableDependencyRule.php
new file mode 100644
index 00000000..74e711bd
--- /dev/null
+++ b/src/Rules/Drupal/CacheableDependencyRule.php
@@ -0,0 +1,79 @@
+<?php
+
+declare(strict_types=1);
+
+namespace mglaman\PHPStanDrupal\Rules\Drupal;
+
+use Drupal\Core\Cache\CacheableDependencyInterface;
+use Drupal\Core\Cache\CacheableResponseInterface;
+use Drupal\Core\Cache\RefinableCacheableDependencyInterface;
+use Drupal\Core\Plugin\Context\ContextInterface;
+use Drupal\Core\Render\RendererInterface;
+use PhpParser\Node;
+use PhpParser\Node\Identifier;
+use PHPStan\Analyser\Scope;
+use PHPStan\Rules\Rule;
+use PHPStan\Rules\RuleErrorBuilder;
+use PHPStan\Type\ObjectType;
+
+/**
+ * @implements Rule<Node\Expr\MethodCall>
+ */
+class CacheableDependencyRule implements Rule
+{
+
+    public function getNodeType(): string
+    {
+        return Node\Expr\MethodCall::class;
+    }
+
+    public function processNode(Node $node, Scope $scope): array
+    {
+        if (!$node->name instanceof Identifier || $node->name->toString() !== 'addCacheableDependency') {
+            return [];
+        }
+
+        $receiverType = $scope->getType($node->var);
+
+        $allowedInterfaces = [
+            RefinableCacheableDependencyInterface::class => 0,
+            CacheableResponseInterface::class => 0,
+            ContextInterface::class => 0,
+            RendererInterface::class => 1,
+        ];
+
+        $argumentIndex = null;
+        foreach ($allowedInterfaces as $interfaceName => $argPosition) {
+            $interfaceType = new ObjectType($interfaceName);
+            if ($interfaceType->isSuperTypeOf($receiverType)->yes()) {
+                $argumentIndex = $argPosition;
+                break;
+            }
+        }
+
+        if ($argumentIndex === null) {
+            return [];
+        }
+
+        $args = $node->getArgs();
+        if (count($args) <= $argumentIndex) {
+            return [];
+        }
+
+        $dependencyArg = $args[$argumentIndex]->value;
+        $object = $scope->getType($dependencyArg);
+
+        $interfaceType = new ObjectType(CacheableDependencyInterface::class);
+        $implementsInterface = $interfaceType->isSuperTypeOf($object);
+
+        if (!$implementsInterface->no()) {
+            return [];
+        }
+
+        return [
+            RuleErrorBuilder::message('Calling addCacheableDependency($object) when $object does not implement CacheableDependencyInterface effectively disables caching and should be avoided.')
+                ->identifier('cacheable.dependency')
+                ->build(),
+        ];
+    }
+}
diff --git a/tests/src/Rules/CachableDependencyRuleTest.php b/tests/src/Rules/CachableDependencyRuleTest.php
new file mode 100644
index 00000000..d4fef310
--- /dev/null
+++ b/tests/src/Rules/CachableDependencyRuleTest.php
@@ -0,0 +1,51 @@
+<?php declare(strict_types=1);
+
+namespace mglaman\PHPStanDrupal\Tests\Rules;
+
+use mglaman\PHPStanDrupal\Rules\Drupal\CacheableDependencyRule;
+use mglaman\PHPStanDrupal\Tests\DrupalRuleTestCase;
+
+final class CachableDependencyRuleTest extends DrupalRuleTestCase {
+
+    protected function getRule(): \PHPStan\Rules\Rule
+    {
+        return new CacheableDependencyRule();
+    }
+
+    /**
+     * @dataProvider resultData
+     *
+     * @param list<array{0: string, 1: int, 2?: string|null}> $errorMessages
+     */
+    public function testRule(string $path, array $errorMessages): void
+    {
+        $this->analyse([$path], $errorMessages);
+    }
+
+    public static function resultData(): \Generator
+    {
+        yield 'all test cases' => [
+            __DIR__ . '/data/cacheable-dependency.php',
+            [
+                [
+                    'Calling addCacheableDependency($object) when $object does not implement CacheableDependencyInterface effectively disables caching and should be avoided.',
+                    13
+                ],
+                [
+                    'Calling addCacheableDependency($object) when $object does not implement CacheableDependencyInterface effectively disables caching and should be avoided.',
+                    36
+                ],
+                [
+                    'Calling addCacheableDependency($object) when $object does not implement CacheableDependencyInterface effectively disables caching and should be avoided.',
+                    39
+                ],
+                [
+                    'Calling addCacheableDependency($object) when $object does not implement CacheableDependencyInterface effectively disables caching and should be avoided.',
+                    55
+                ],
+            ]
+        ];
+    }
+
+
+}
diff --git a/tests/src/Rules/data/cacheable-dependency.php b/tests/src/Rules/data/cacheable-dependency.php
new file mode 100644
index 00000000..5964dc0b
--- /dev/null
+++ b/tests/src/Rules/data/cacheable-dependency.php
@@ -0,0 +1,59 @@
+<?php
+
+namespace Drupal\phpstan_fixtures;
+
+use Drupal\Core\Cache\CacheableMetadata;
+
+class UsesIncorrectCacheableDependency {
+    public function test() {
+        $element = [];
+        $cacheable_metadata = CacheableMetadata::createFromRenderArray($element);
+
+        $object = new \Stdclass;
+        $cacheable_metadata->addCacheableDependency($object);
+    }
+}
+
+class UsesCorrectCacheableDependency {
+    public function test() {
+        $element = [];
+        $cacheable_metadata = CacheableMetadata::createFromRenderArray($element);
+
+        $correct_dependency = new CacheableMetadata();
+        $cacheable_metadata->addCacheableDependency($correct_dependency);
+    }
+}
+
+class MultipleCacheableDependencyCalls {
+    public function test() {
+        $element = [];
+        $cacheable_metadata = CacheableMetadata::createFromRenderArray($element);
+
+        $correct_dependency = new CacheableMetadata();
+        $cacheable_metadata->addCacheableDependency($correct_dependency);
+
+        $object = new \StdClass;
+        $cacheable_metadata->addCacheableDependency($object);
+
+        $another_object = new \DateTime();
+        $cacheable_metadata->addCacheableDependency($another_object);
+    }
+}
+
+class RendererInterfaceTestCase {
+    public function testCorrectUsage(\Drupal\Core\Render\RendererInterface $renderer) {
+        $elements = [];
+
+        $correct_dependency = new CacheableMetadata();
+        $renderer->addCacheableDependency($elements, $correct_dependency);
+    }
+
+    public function testIncorrectUsage(\Drupal\Core\Render\RendererInterface $renderer) {
+        $elements = [];
+
+        $object = new \StdClass;
+        $renderer->addCacheableDependency($elements, $object);
+    }
+}
+
+