There seems to be a problem with CRM general settings. Here's how to reproduce:
- Go to Settings > General Settings > CRM
- Activate "Leads"
- Activate "Manual Assignation..."
- Save
- Go back to CRM General Settings
At this point, Lead should keep settings (but it seems that this is not happening)...
Sorry for not being able to help further... I'n not a developer :(
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