diff --git a/httpx/_decoders.py b/httpx/_decoders.py
index 899dfada87..9043c1cf6e 100644
--- a/httpx/_decoders.py
+++ b/httpx/_decoders.py
@@ -176,6 +176,7 @@ def __init__(self) -> None:
 
         self.decompressor = zstandard.ZstdDecompressor().decompressobj()
         self.seen_data = False
+        self.seen_eof = False
 
     def decode(self, data: bytes) -> bytes:
         assert zstandard is not None
@@ -187,6 +188,11 @@ def decode(self, data: bytes) -> bytes:
                 unused_data = self.decompressor.unused_data
                 self.decompressor = zstandard.ZstdDecompressor().decompressobj()
                 output.write(self.decompressor.decompress(unused_data))
+            # If the decompressor reached EOF, create a new one for the next call
+            # since zstd decompressors cannot be reused after EOF
+            if self.decompressor.eof:
+                self.seen_eof = True
+                self.decompressor = zstandard.ZstdDecompressor().decompressobj()
         except zstandard.ZstdError as exc:
             raise DecodingError(str(exc)) from exc
         return output.getvalue()
@@ -195,7 +201,7 @@ def flush(self) -> bytes:
         if not self.seen_data:
             return b""
         ret = self.decompressor.flush()  # note: this is a no-op
-        if not self.decompressor.eof:
+        if not self.decompressor.eof and not self.seen_eof:
             raise DecodingError("Zstandard data is incomplete")  # pragma: no cover
         return bytes(ret)
 
diff --git a/tests/test_decoders.py b/tests/test_decoders.py
index 9ffaba189d..8f0db9ae44 100644
--- a/tests/test_decoders.py
+++ b/tests/test_decoders.py
@@ -141,6 +141,26 @@ def test_zstd_multiframe():
     assert response.content == b"foobar"
 
 
+def test_zstd_streaming_multiple_frames():
+    body1 = b"test 123 "
+    body2 = b"another frame"
+
+    # Create two separate complete frames
+    frame1 = zstd.compress(body1)
+    frame2 = zstd.compress(body2)
+
+    # Create an iterator that yields frames separately
+    def content_iterator() -> typing.Iterator[bytes]:
+        yield frame1
+        yield frame2
+
+    headers = [(b"Content-Encoding", b"zstd")]
+    response = httpx.Response(200, headers=headers, content=content_iterator())
+    response.read()
+
+    assert response.content == body1 + body2
+
+
 def test_multi():
     body = b"test 123"