diff --git a/dd-java-agent/build.gradle b/dd-java-agent/build.gradle
index 53e9e69e4bd..7f9cfa24a0f 100644
--- a/dd-java-agent/build.gradle
+++ b/dd-java-agent/build.gradle
@@ -104,6 +104,31 @@ def generalShadowJarConfig(ShadowJar shadowJarTask) {
     exclude '**/io/airlift/compress/snappy/**'
     relocate 'io.airlift', 'datadog.io.airlift'
 
+    // Minimize JNA, removing native libraries for unsupported environments
+    exclude '**/com/sun/jna/aix-*/**'
+    exclude '**/com/sun/jna/freebsd-*/**'
+    exclude '**/com/sun/jna/linux-armel/**'
+    exclude '**/com/sun/jna/linux-mips64el/**'
+    exclude '**/com/sun/jna/linux-ppc/**'
+    exclude '**/com/sun/jna/linux-ppc64le/**'
+    exclude '**/com/sun/jna/linux-riscv64/**'
+    exclude '**/com/sun/jna/linux-s390x/**'
+    exclude '**/com/sun/jna/openbsd-*/**'
+    exclude '**/com/sun/jna/sunos-*/**'
+
+    // Minimize JFFI, removing native libraries for unsupported environments
+    exclude '**/jni/*-AIX/**'
+    exclude '**/jni/*-DragonFlyBSD/**'
+    exclude '**/jni/*-FreeBSD/**'
+    exclude '**/jni/loongarch64-Linux/**'
+    exclude '**/jni/mips64el-Linux/**'
+    exclude '**/jni/ppc64-Linux/**'
+    exclude '**/jni/ppc64le-Linux/**'
+    exclude '**/jni/s390x-Linux/**'
+    exclude '**/jni/sparcv9-Linux/**'
+    exclude '**/jni/*-OpenBSD/**'
+    exclude '**/jni/*-SunOS/**'
+
     final String projectName = "${project.name}"
 
     // Prevents conflict with other instances, but doesn't relocate instrumentation