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Hi Mark,
I have uploaded a new branch of SigProfilerExtractor. There, I made some modification in the BootstrapCancerGenome, pnmf, and paraller_runs fuctions. I found using numpy matrix with OPENBLAS_NUM_THREADS=1 significantly improved the Boostrap computation to prepare the data with Poisson noise on my machine. I would like to check how your machines behave with the code and if this changes retain the same accuracy.
Thanks,
Mishu